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Opal Journal

PDRN Salmon DNA: Korea’s Regenerative Skin Secret, Explained

The most interesting treatment to cross over from Korean dermatology is PDRN.

What it is

Polydeoxyribonucleotide: purified DNA fragments from salmon, highly biocompatible with human tissue and used in regenerative medicine since the 1990s.

How it works

PDRN binds adenosine A2A receptors, switching on fibroblast activity, collagen synthesis and anti-inflammatory repair. We deliver it via mesoneedling so it reaches the dermis where it works.

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